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AssigneeNew York University
InventorsBenjamin NEEL, Abhishek Bhardwaj
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This application provides methods of inhibiting an inflammation- or hypoxia-induced death of a cell involving inhibiting an RNF213 signaling pathway. The application further provides methods of preventing or treating various diseases and disorders in a subject involving administering to the subject an inhibitor of expression of RNF213 protein or an inhibitor of one or more functions of the RNF213 protein. The application still further provides methods for enhancing the effectiveness of a cancer treatment in a subject where the cancer involves a hypoxic tumor microenvironment involving co-administering the cancer treatment with an inhibitor or activator of different functions of the RNF213 protein. The application also provides methods of eliminating drug-resistant tumor cells by co-administering an inhibitor of the expression of RNF213 protein or by inhibiting or activating specific functions of the RNF213 protein.
A method of inhibiting inflammatory cell death or hypoxia-induced cell death in a subject in need thereof, comprising
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A method of preventing or treating a vascular occlusive event or disorder in a subject in need thereof, comprising
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A method of preventing or treating an autoimmune or inflammatory disease in a subject in need thereof, comprising
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A method of preventing or treating a disease associated with lipotoxicity in a subject in need thereof, comprising
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Dependencies are inferred from the claim text.