US 2025/0025459 A1 · COVID-19 TREATMENT MEDICINE CHARACTERIZED BY COMBINING 3CL PROTEASE INHIBITOR AND COVID-19 TREATMENT DRUG

Abstract

The present invention provides a medicament useful in treatment and/or prevention, etc. of COVID-19. Provided is a medicament characterized by combining (A) a compound represented by Formula (I): wherein Y is N; R1 is substituted or unsubstituted aromatic heterocyclyl; R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl; R3 is substituted or unsubstituted aromatic heterocyclyl; —X— is —NH—; m is 0 or 1; R5a is a hydrogen atom; R5b is a hydrogen atom; n is 1; R4a is a hydrogen atom; and R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof; and (B) a COVID-19 exacerbation suppressant.

Claims16

Dependent claims

A medicament characterized by combining (A) a compound represented by Formula (I):

wherein Y is N;
R1 is substituted or unsubstituted aromatic heterocyclyl;
R2 is substituted or unsubstituted 6-membered aromatic carbocyclyl;
R3 is substituted or unsubstituted aromatic heterocyclyl;
—X— is —NH—;
m is 0 or 1;
R5a is a hydrogen atom;
R5b is a hydrogen atom;
n is 1;
R4a is a hydrogen atom;
and
R4b is a hydrogen atom, or a pharmaceutically acceptable salt thereof;
and
(B) a COVID-19 exacerbation suppressant (provided that, excluding the compound represented by Formula (I) or a pharmaceutically acceptable salt thereof).

11 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/711,747Filed 25 Nov 2022

Priority

JP 2021-19163626 Nov 2021

Published

23 Jan 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

A61K 31/495
Having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins: having six-membered rings with two or more nitrogen atoms as the only ring…
A61K 31/235
Of carboxylic acids: having an aromatic ring attached to a carboxyl group
A61K 31/403
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: condensed with…
A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol

Covid-19 treatment medicine characterized by combining 3cl protease inhibitor and covid-19 treatment drug

Life of this patent

Covid-19 treatment medicine characterized by combining 3cl protease inhibitor and covid-19 treatment drug

Life of this patent

Abstract

Claims16