Pharmaceutical composition and a process to prepare the same
AssigneeGodavari Biorefineries Limited
InventorsVijayendra REDASANI, Sandip GAVADE, Maithili ATHAVALE, Prashant KHARKAR
Life of this patent
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Abstract
The present invention relates to pharmaceutical compositions comprising compound of Formula IV, along with a solubilizing agent and a process to prepare the same. The said pharmaceutical compositions have enormous applications in cancer therapy. The present invention has come up with a novel and innovative pharmaceutical composition for the compounds of Formula IV that show significant stability as well as the desired bioavailability on drug release.
Claims23
A pharmaceutical composition comprising the compound of Formula IV or its pharmaceutically acceptable salt thereof,
- wherein R6 and R7 each independently is selected from —H, alkoxy, alkyl, substituted or unsubstituted aromatic group, —NH2, —NO2, —NHCOCH3, —CN, —O—, halogen, —OCF3 or R6 and R7 together form a heterocyclic ring;
- R11 and R12 each independently is selected from —H, or R11 and R12 can be substituted or unsubstituted 5- or 6-membered ring such as lactone, —C(O)O-alkyl such as —C(O)OC2H5;
- R is selected from
- —H, —C(O)CH2Cl, —SOO—CH3, —SOOPh, —CH2C(O)N(CH3)2, —C(O)NHPh, —C(O)NHPhOH, —C(S)NHPh, —CH2Ph, —COAr, —SOOAr, —CONHAr, —CH2Ar, —CSNHAr, wherein, R13 is selected from —OH, —NH2, —NHCOCH3, X═F, Cl, Br, alkyl, acetyl, C3-C8 acyl group;
- R14 is selected from alkoxy, —OMe, —OH, NH2, —NHCOCH3, X═F, Cl, Br, alkyl, acetyl, C3-C8 acyl group;
- R15 is selected from alkoxy, —OMe, —OH, —H, Br, NH2, X═F, Cl, Br, alkyl, acetyl, C3-C8 acyl group;
- R16 is selected from —H, —CH2OH, —OH, alkyl, alkoxy, R17 is selected from alkyl;
- and a solubilizing agent, further wherein the compound or a pharmaceutically acceptable salt of Formula IV, in the said pharmaceutical composition is amorphous.
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A method of treating cancer or cancer related diseases in an individual, comprising administering to the individual an effective amount of the pharmaceutical composition comprising any of the compound of Formula IV along with a solubilizing agent.
Dependencies are inferred from the claim text.