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US 2025/0025429 A1Published application
Lipid nanoparticles for oligonucleotide delivery
AssigneeZiphius NV
InventorsSophie VALEMBOIS, Ashiqul HAQUE AKM, Itishri SAHU, Séan MC CAFFERTY, Christiaan CARDON
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Abstract
The current invention relates to ionizable lipid-like compounds according to Formula (I) or pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The present invention also provides a lipid nanoparticle comprising an ionizable lipid-like compound according to Formula I and one or more RNA molecules, as well as a pharmaceutical composition or vaccine, comprising such lipid nanoparticles.
Claims19
A compound according to Formula (I) or pharmaceutically acceptable salt, tautomer, or stereoisomer thereof,
- wherein:
- Z1 is hydroxyl or primary amine;
- q is 0, 1, 2, 3 or 4;
- p is 1, 2, 3, 4 or 5;
- each m is, independently, 1, 2, 3, 4 or 5;
- R1 is -L1N [L2F1RA]2 or -L3F2RB and R2 is -L4F3RC, wherein:
- each L1, L2, L3 and L4 are, independently, C2-C10 alkylene, each F1, F2 and F3 are, independently, ester or amide functional group and each RA, RB and RC are, independently, branched C4-C30 alkyl.
4 more elements
Dependencies are inferred from the claim text.