Ternary co-amorphous forms of drugs, proteins, and water-soluble polymers
AssigneeZerion Pharma Aps
InventorsKorbinian Löbmann, Donglei Leng, Wei Tian, Bulut Bulduk, Ole Wiborg
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Abstract
The present invention concerns ternary co-amorphous forms including a drug compound, a nutraceutical, or a dietary supplement in combination with a protein and a water-soluble polymer. Co-amorphous forms are a combination of three or more components that form a homogeneous amorphous system where the components are intimately mixed on the molecular level. The ternary co-amorphous forms of the invention provide increased solubility and dissolution rate of drug compounds, nutraceuticals, and dietary supplements. This in turn increases the bioavailability of these compounds.
Claims11
A co-amorphous form of a drug, a nutraceutical, or a dietary supplement with a protein and a water-soluble polymer, wherein the protein is beta-lactoglobulin.
2-10. (canceled)
A method for preparing a protein and a water-soluble polymer in a co-amorphous form with a drug, nutraceutical, or dietary supplement, comprising incorporating beta-lactoglobulin, a water-soluble polymer, and a drug, nutraceutical, or dietary supplement in a co-amorphous form.
A co-amorphous form of a drug, a nutraceutical, or a dietary supplement with a protein and a water-soluble polymer, wherein the water-soluble polymer is selected from polyvinyl pyrrolidone, Poloxamer type polymers, polymethacrylate-based copolymers, polystyrene sulfonate, or any mixture thereof.
Dependencies are inferred from the claim text.