Hyaluronic acid-lipid derivative, lipid nanoparticle comprising same, and use thereof
AssigneesGenexine, Inc., Phi Biomed Inc., Postech Research and Business Development Foundation
InventorsSei Kwang HAHN, Young Chul SUNG, Daham JEONG, Mun Gu KIM, Hwan Hee KIM
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Abstract
A hyaluronic acid-lipid derivative, lipid nanoparticles comprising the same, and uses thereof are disclosed. The lipid nanoparticles comprising the hyaluronic acid-lipid derivative can be utilized as a vaccine or a drug delivery carrier for effectively carrying mRNA, proteins and other drugs, and stably delivering same into the body, and such a vaccine or drug delivery carrier has excellent mucoadhesive properties and mucosal permeability and thus has the advantage of enabling vaccine or drug delivery via the nasal cavity and lungs.
Claims20
A lipid nanoparticle, comprising a hyaluronic acid-lipid derivative.
A hyaluronic acid-lipid derivative, which is represented by any one of Chemical Formulas 1 to 4 below:
- wherein in Chemical Formulas 1 to 5, n is an integer from 1 to 50, and in Chemical Formula 5, A is an aldehyde group.
Dependencies are inferred from the claim text.