Specially formulated compositions of inhaled nintedanib and nintedanib salts

A method to administer an aerosol formulation of nintedanib comprising:

• 1) combining a sealed, sterile first solution containing a dissolved nintedanib salt, wherein the salt counterion is selected from the group consisting of esylate, chloride, and bromide and combinations thereof with a separate sealed, sterile second solution comprised of permeant ions to adjust the permeant ion concentration of an admixture of the first and second solution to between 30 mM and 150 mM and wherein either or both of the first or second solution is further comprised of an osmolality adjusting agent that increases the osmolality of the admixture and avoids precipitation of the nintedanib salt;
• 2) containing the admixture in the reservoir of a nebulizer;
• 3) activating the nebulizer to deliver by inhalation an aerosol dose of the nintedanib salt to the lungs of a patient to reduce a progression of a decline in Forced Vital Capacity (FVC) or Forced Expiratory Volume (FEV1).