An oil-in-water emulsion gel comprising tiotropium bromide
AssigneeDryox Health, S.L.
InventorsOriol SOLÀ-MORALES I SERRA, Maria BUXADÉ FORTUNY
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Abstract
The present invention relates to an oil-in-water emulsion gel comprising tiotropium bromide for topical use. It can be used in cosmetics, as an antiperspirant or in the prevention and/or treatment of hyperhidrosis. After application to the skin nanoparticles are formed and the drug substance penetrates the skin where it exerts its effect. The oil-in-water emulsion gel is composed in such a manner that the drug substance permeates the epidermis and enters into the dermis, but only to a minor extent permeating through the dermis and into the systemic circulation.
Claims15
A dermatologically acceptable oil-in-water emulsion gel comprising tiotropium bromide.
2-15. (canceled)
A method for preparing an oil-in-water emulsion gel comprising tiotropium bromide, the method comprising:
- i) preparing an hydroalcoholic gel comprising one or more water-soluble cellulose derivatives,
- ii) preparing an organic phase comprising tiotropium bromide, and
- iii) mixing the hydroalcoholic gel with the organic phase comprising tiotropium bromide to obtain said oil-in-water emulsion gel.
Dependencies are inferred from the claim text.