Devices for acute and chronic flow modification in body lumens and methods of use thereof

A flow modulator device for altering fluid flow through a body lumen, the body lumen coupled to a branch lumen, the flow modulator device comprising:

• a stent configured to be positioned within the body lumen, the stent comprising an upstream component having an inlet, an outlet, and a cross-sectional flow area that converges from the inlet towards the outlet to form a nozzle, at least a portion of the nozzle configured to be radially expandable responsive to pressure upstream of the flow modulator device within the body lumen, a downstream component having an entry, an exit, and a cross-sectional flow area that diverges from the entry towards the exit, and an entrainment region between the inlet of the upstream component and the exit of the downstream component, the entrainment region comprising one or more openings,
• wherein the nozzle is configured to accelerate a fluid stream passing through the upstream component towards the downstream component to generate a low pressure region in a vicinity of the entrainment region that entrains additional fluid into the fluid stream via the one or more openings as the fluid stream passes into the downstream component.