Catheter with lubricious coating for distal access to the vasculature including the neurovasculature
AssigneeJulier Medical AG
InventorNiall BEHAN
Life of this patent
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Abstract
Systems and methods are provided for applying a lubricious coating to a catheter such as a catheter for distal access and/or removing an obstruction from or clot from a blood vessel, e.g., in the neurovasculature. A lubricious coating may be applied to an inner and outer surface of the elongated tube of the catheter. For example, an expandable braid at a distal portion of the catheter may be coated on its inner and outer surfaces to facilitate advancement through the vasculature and slidability of a catheter shaft within the expandable braid.
Claims20
A catheter system for advancement in a vasculature to a target site in a blood vessel, the catheter system comprising:
- an elongated tube comprising a proximal section and an expandable distal section, the expandable distal section comprising an inner coating forming an inner lubricious surface and an outer coating, the expandable distal section with the inner coating and the outer coating configured to transition from a contracted state to an expanded state at the target site in the blood vessel for performing an intervention;
- and
- an inner elongated tube configured to be advanced into the expandable distal section in the expanded state via the inner lubricious surface.
A method for applying a lubricious coating to a neurovascular catheter, the method comprising:
- selecting a catheter comprising an elongated tube comprising a proximal section and a braided section at a distal end, the elongated tube having an inner surface and an outer surface each comprising silicone or polyurethane, the catheter adapted to remove an obstruction from a blood vessel;
- exposing a distal portion of the catheter comprising the braided section and at least part of the proximal section to a first solution comprising methyl acetate for a first duration;
- exposing, after exposing the distal portion of the catheter to the first solution, the distal portion of the catheter to a second solution comprising (3-Aminopropyl) triethoxysilane (APTES) for a second duration;
- exposing, after exposing the distal portion of the catheter to the second solution, the distal portion of the catheter to a lubricious coating solution comprising a poly(methyl vinyl ether-maleic acid) copolymer to apply a lubricous coating to the distal portion of the catheter;
- and
- heating, after exposing the distal portion of the catheter to the lubricious coating solution, the distal portion of the catheter at a first temperature for a third duration.
A method for applying a lubricious coating to a neurovascular catheter, the method comprising:
- selecting a catheter comprising an elongated tube comprising a proximal section and a braided section at a distal end, the elongated tube having an inner surface and an outer surface each comprising silicone or polyurethane, the catheter adapted to remove an obstruction from a blood vessel;
- exposing a distal portion of the catheter comprising the braided section and at least part of the proximal section to a first solution comprising methyl acetate for a first duration;
- exposing, after exposing the distal portion of the catheter to the first solution, the distal portion of the catheter to a second solution comprising (3-Aminopropyl) triethoxysilane (APTES) for a second duration;
- selecting a reactive primer solution comprising Polyethylenimie (PEI) reacted with an N-Hydroxysuccinimide (NHS) grafted Perfluorophenylazide (PFPA) in ethanol;
- exposing, after exposing the distal portion of the catheter to the second solution, the distal portion of catheter to the reactive primer solution;
- and
- exposing, after exposing the distal portion of the catheter to the primer coating, the distal portion of catheter to a lubricious coating solution comprising a poly(methyl vinyl ether-maleic acid) copolymer to apply a lubricous coating to the distal end of the catheter.
Dependencies are inferred from the claim text.