Aspiration systems and methods for removal of undesired material from a circulatory system

A method for removing an undesired material from a vasculature, the method comprising:

• providing an aspiration system with a distal end proximate the undesired material, the aspiration system comprising:
• a first sheath assembly comprising a first elongate shaft and a first hub at a proximal end of the first elongate shaft, wherein the first hub includes a hemostasis valve including a first multi-durometer sealing gland and a side port configured to be operatively coupled to a first suction source;
• a cannula comprising a cannula shaft configured to be inserted within the first sheath assembly and to be operatively coupled to a second suction source, wherein the first multi-durometer sealing gland is configured to selectively close to seal around the cannula shaft or completely close when the cannula shaft is not positioned within the first sheath assembly, and
• a second sheath assembly comprising a second elongate shaft having a tapered distal end and a second hub at a proximal end of the second elongate shaft, wherein the second hub includes a hemostasis valve having a second multi-durometer seal, and wherein the first elongate shaft of the first sheath assembly is configured to be inserted into the second elongate shaft of the second sheath assembly and the second multi-durometer seal of the second sheath assembly is configured to seal around the first elongate shaft of the first sheath assembly;
• actuating the second suction source to generate a suction force through the cannula shaft to remove a first portion of the undesired material from a vessel of the vasculature;
• removing the cannula shaft from the first sheath assembly;
• and
• actuating the first suction source to remove a second portion of the undesired material from the vessel of the vasculature via the first elongate shaft and the side port of the first hub of the first sheath assembly.