Devices and methods involving metadevices and photonic-based biosensing

An apparatus comprising:

• a functionalized metasurface sensor including an array of guided-mode resonance metasurface biosensor pixels (“GMR pixels”), wherein each of the GMR pixels has a cavity section to support GMR at a certain Q and is functionalized for attachment of a distinct receptor or probe molecules;
• optics, coupled at respective ends of each of the GMR pixels, to contain light and optimally mitigate energy losses due to scattering of light, in response to light being directed towards the metasurface sensor;
• and
• light-responsive and data-processing circuitry, responsive to the directed light manipulated by a biological sample at respective ones of the distinct receptor or probe molecules, to distinguish between different types of biological molecules in the biological sample.

A method comprising:

• functionalizing a metasurface sensor including an array of guided-mode resonance metasurface biosensor pixels (“GMR pixels”), by attaching a distinct receptor or probe molecules to respective ones of the GMR pixels;
• and
• with each of a plurality of the GMR pixels including optics secured at respective ends of the GMR pixel and including a cavity section to support GMR at a certain Q, directing light towards the metasurface sensor and containing light and thereby mitigating energy losses due to scattering of light, and
• using circuitry to respond to the directed light, after being manipulated by a biological sample at respective ones of the GMR pixels, to distinguish different types of biological molecules in the biological sample.