Circulating tumor dna fraction and uses thereof
AssigneeFoundation Medicine, Inc.
InventorsGeoffrey R. OXNARD, Hanna TUKACHINSKY, Russell MADISON
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Abstract
Disclosed herein are methods of treating an individual having cancer, of treating or identifying an individual having cancer for a treatment, or stratifying individuals having cancer for a treatment based on a tumor shed value determination in a liquid biopsy sample. Also described herein are methods of analyzing a biomarker based on a tumor shed value determination in a liquid biopsy sample.
Claims36
(canceled)
A method of treating an individual having a cancer with an immuno-oncology (IO) therapy and chemotherapy combination comprising (a) determining a tumor shed value for a liquid biopsy sample obtained from the individual, and (b) treating the individual with the IO therapy and chemotherapy combination if the tumor shed value in the liquid biopsy sample is equal to or higher than a reference tumor shed value.
3-7. (canceled)
A method of treating an individual having a cancer with an immuno-oncology (IO) therapy comprising (a) determining a tumor shed value for a liquid biopsy sample obtained from the individual, and (b) treating the individual with the IO if the tumor shed value in the liquid biopsy sample is lower than a reference tumor shed value.
9-14. (canceled)
A method of treating an individual having a cancer with a first therapy and a second therapy comprising (a) determining a tumor shed value for a liquid biopsy sample obtained from the individual, and (b) treating the individual with the first therapy and the second therapy if the tumor shed value in the liquid biopsy sample is equal to or greater than a reference tumor shed value.
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Dependencies are inferred from the claim text.