Luciferase-Intercalating Dye Conjugates for Ratiometric Nucleic Acid Detection
AssigneeTechnische Universiteit Eindhoven
InventorsYosta de Stigter, Bas Rosier, Maarten Merkx
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Abstract
Disclosed herein are probes for detecting and quantifying double stranded DNA. The probes comprise a luminescence generating domain and an intercalating fluorescent dye. The probes may be used in quantitative DNA amplification reactions. Further disclosed are methods of detecting or quantifying double stranded DNA using the probes described herein. Also described are uses of the probes in detecting or quantifying DNA.
Claims14
An intercalating dye probe for detection of double stranded DNA, wherein the dye comprises a luminescence generating protein linked to one or more intercalating fluorescent dyes.
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