Gata4-targeted therapeutics for treatment of cardiac hypertrophy
AssigneeUniversity of Rochester
InventorsPeng YAO, Omar HEDAYA
Life of this patent
Estimating the term…
Abstract
The present application provides compositions and methods for treating cardiac hypertrophy. In one embodiment, the composition comprises an antisense oligonucleotide 10-50 nucleotides in length, wherein the antisense oligonucleotide is capable of forming a double-stranded structure with a target region downstream of a start codon of an upstream open reading frame (uORF) resided within an mRNA of GATA4, wherein the target region spans a double-stranded stem of a stem-loop structure downstream of the GATA4 uORF start codon
Claims20
An antisense oligonucleotide comprising 10-50 nucleotides, wherein the antisense oligonucleotide is capable of forming a double-stranded structure with a target region downstream of a start codon of an upstream open reading frame (uORF) resided within an mRNA of GATA4, wherein the antisense oligonucleotide comprises one or more modified nucleotides, wherein the target region spans a double-stranded stem of a stem-loop structure downstream of the start codon.
Dependencies are inferred from the claim text.