Treatment for inflammatory disease

Abstract

The present disclosure relates to a method of treating or preventing a disease in an individual, the method comprising reducing pyroptosis by administering to the individual a composition comprising an agent whose administration reduces TSPO signalling in the individual. The method of the disclosure can thus be used to treat or prevent diseases associated with pyroptosis such as inflammatory disease, cancer, neurodegenerative disease, cardiovascular disease, kidney disease and sepsis. The disclosure also relates to use of TSPO expression as a biomarker for pyroptosis, a method of assessing the degree of pyroptosis in an individual based on TSPO expression, an in vitro model of pyroptosis, a method of producing the in vitro model and associated vector, and a method for determining the ability of an agent to inhibit pyroptosis.

Dependencies are inferred from the claim text.