Compositions and methods for rare heparan sulfate glycan-targeted cancer treatment
AssigneeBoard of Regents, The University of Texas System
InventorsKiyoshi ARIIZUMI, Jin-Sung CHUNG, Ponciano D. CRUZ, Jr.
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Abstract
Provided herein are single domain antibodies (sdAbs) having a specific affinity for a rare heparan sulfate moiety which can be used to disrupt DC-HIL function to reduce and prevent cancer progression and metastasis. Compositions and methods of use thereof are also provided for use of these sdAbs to treat cancer and cancer metastasis in a subject in need thereof.
Claims32
A single domain antibody (sdAb) comprising a variable heavy domain having a specific affinity for a heparan sulfate glycan having a structure of Formula I (GlcNS6S-GlcA-GlcNS6S-IdoA2S-GlcNS6S-IdoA2S-GlcNS6S-GlcA)
Dependencies are inferred from the claim text.