US 2025/0019462 A1 · ANTIBODIES THAT SPECIFICALLY BIND TO API5 PROTEIN

Abstract

The present invention relates to an antibody specifically binding to apoptosis inhibitor 5 (API5) protein and uses thereof. The antibody or antigen-binding fragment thereof that specifically binds to APIS according to the present invention can have excellent anticancer effects, such as inhibiting phosphorylation of ERK in cancer cells and inhibiting cancer growth. In addition, the antibody or antigen-binding fragment thereof exhibits excellent anticancer effects against cancers that are resistant or refractory to anticancer drugs. Accordingly, it is useful for preventing or treating cancers resistant or refractory to anticancer drugs as well as general cancers.

Claims7

Dependent claims

An antibody or antigen-binding fragment thereof that specifically binds to apoptosis inhibitor 5 (API5) comprising:

a heavy chain CDR1 comprising the amino acid sequence GFTFSTYA of SEQ ID NO:
1;
a heavy chain CDR2 comprising the amino acid sequence ISGSGGLT of SEQ ID NO:
4;
a heavy chain CDR3 comprising the amino acid sequence AKLVLEWFYFSMDH of SEQ ID NO:
8;
a light chain CDR1 comprising the amino acid sequence QSISRY of SEQ ID NO:
16;
a light chain CDR2 comprising the amino acid sequence AAS of SEQ ID NO:
17;
and
a light chain CDR3 comprising the amino acid sequence QQSYSFPWT of SEQ ID NO:
18.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/900,599Filed 27 Sep 2024

Priority

KR 10-2022-003998230 Mar 2022

Published

16 Jan 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 16/32
Against material from animals or humans: against translation products of oncogenes
A61P 35/00
Antineoplastic agents
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies
C07K 16/18
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material from animals or humans

Antibodies that specifically bind to api5 protein

Life of this patent

Antibodies that specifically bind to api5 protein

Life of this patent

Abstract

Claims7