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US 2025/0019461 A1Published application
Her3 antigen-binding molecules
AssigneeHummingbird Bioscience Pte. Ltd.
InventorsJerome Douglas Boyd-Kirkup, Piers Ingram, Dipti Thakkar, Zhihao Wu, Konrad Paszkiewicz, Vicente Sancenon, Siyu Guan
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Abstract
HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules.
Claims23
An antigen-binding molecule, optionally isolated, which is capable of binding to HER3, wherein the antigen-binding molecule comprises:
- (i) a heavy chain variable (VH) region incorporating the following CDRs:
- HC-CDR1 having the amino acid sequence of SEQ ID NO:43
- HC-CDR2 having the amino acid sequence of SEQ ID NO:46
- HC-CDR3 having the amino acid sequence of SEQ ID NO:51;
- and
- (ii) a light chain variable (VL) region incorporating the following CDRs:
- LC-CDR1 having the amino acid sequence of SEQ ID NO:91
- LC-CDR2 having the amino acid sequence of SEQ ID NO:94
- LC-CDR3 having the amino acid sequence of SEQ ID NO:99.
6 more elements
The antigen-binding molecule according to any one of claims 1 to 6, wherein the antigen-binding molecule comprises:
- (i) a heavy chain variable (VH) region incorporating the following CDRs:
- HC-CDR1 having the amino acid sequence of SEQ ID NO:41
- HC-CDR2 having the amino acid sequence of SEQ ID NO:45
- HC-CDR3 having the amino acid sequence of SEQ ID NO:48;
- and
- (ii) a light chain variable (VL) region incorporating the following CDRs:
- LC-CDR1 having the amino acid sequence of SEQ ID NO:88
- LC-CDR2 having the amino acid sequence of SEQ ID NO:92
- LC-CDR3 having the amino acid sequence of SEQ ID NO:95.
6 more elements
Dependencies are inferred from the claim text.