Anti-trop2 antibodies in immunosuppressed subjects
AssigneeADRIATX S.r.l.
InventorSaverio ALBERTI
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Abstract
It forms an object of the present invention a composition comprising the 4F6 anti-Trop-2 antibody and/or its conjugates for use in the treatment of a Trop-2-expressing tumors in a subject, wherein said subject is immunosuppressed by anticancer treatments, such as chemotherapy or radiotherapy.
Claims8
A method of treatment of a Trop-2-expressing tumors in an immunosuppressed subject, wherein said immunosuppression is due to anti-tumor treatment, including chemotherapy and radiation, said method comprising administering a composition comprising the 4F6 anti-Trop-2 antibody and/or its conjugates.
A method for imaging of metastatic immunosuppressed patients by positron-emission tomography, comprising administering 4F6 anti-Trop-2 antibodies conjugated to positron emitters or conjugated to fluorescent tracers.
Dependencies are inferred from the claim text.