Proteins comprising cd20 binding domains, and uses thereof
AssigneePharmaceutica NV
InventorsSrinivasa R. BANDI, Jun CHEN, Jinquan LUO, Elisabeth Geyer PRINSLOW, Sanjaya SINGH, Danlin YANG
Life of this patent
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Abstract
The invention provides antigen binding domains that bind Cluster of Differentiation 20 protein (CD20), proteins comprising the antigen binding domains that bind CD20, polynucleotides encoding them, vectors, host cells, methods of making and using the same.
Claims25
An isolated protein comprising an antigen binding domain that binds Cluster of Differentiation 20 protein (CD20), wherein the antigen binding domain that binds CD20 comprises
- a) a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 12 and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 14;
- b) a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 16 and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 18;
- c) a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 20 and a light chain complementarity determining region (LCDR) 2, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 22;
- or
- d) a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 24 and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 26.
3-10. (canceled)
12-53. (canceled)
56-61. (canceled)
An isolated multispecific protein comprising a first antigen binding domain that binds CD20 and a second antigen binding domain that binds a lymphocyte antigen.
63-66. (canceled)
68-75. (canceled)
78-80. (canceled)
82-96. (canceled)
101-107. (canceled)
109-116. (canceled)
Dependencies are inferred from the claim text.