Anti-ccr8 antibodies and uses thereof
AssigneeHifibio SAS
InventorsJulie PRIGENT, Nicola Arturo Aldo BELTRAMINELLI, Sami ELLOUZE, Francisco ADRIAN, Liang SCHWEIZER, Yun-Yueh LU, Ross Bane FULTON
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Abstract
Anti-CCR8 antibodies and antigen-binding fragments thereof are described herein. Also described herein are nucleic acids encoding the anti-CCR8 antibodies and antigen-binding fragments thereof, compositions comprising the anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of producing and using the anti-CCR8 antibodies and antigen-binding fragments thereof for treating or preventing cancer in a subject in need thereof.
Claims31
An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having a polypeptide sequences of:
- (1) SEQ ID NOs:
- 1, 48, 49, 50, 51, and 6, respectively;
- (2) SEQ ID NOs:
- 1, 2, 3, 4, 5, and 6, respectively;
- (3) SEQ ID NOs:
- 13, 2, 14, 4, 28, and 6, respectively;
- (4) SEQ ID NOs:
- 13, 2, 15, 4, 5, and 6, respectively;
- (5) SEQ ID NOs:
- 16, 17, 18, 29, 30, and 6, respectively;
- (6) SEQ ID NOs:
- 19, 20, 21, 4, 5, and 6, respectively;
- (7) SEQ ID NOs:
- 22, 23, 24, 31, 5, and 32, respectively;
- (8) SEQ ID NOs:
- 25, 26, 27, 33, 34, and 35, respectively;
- (9) SEQ ID NOs:
- 1, 2, 49, 4, 5, and 6, respectively;
- or
- (10) SEQ ID NOs:
- 1, 2, 49, 50, 51, and 6, respectively;
- wherein the antibody or antigen-binding fragment thereof specifically binds chemokine (C—C motif) receptor 8 (CCR8), preferably human CCR8.
-7. (canceled)
An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy chain complementarity determining region 1 (HCDR1), HCDR2, HCDR3, a light chain complementarity determining region 1 (LCDR1), LCDR2, and LCDR3, having a polypeptide sequences of SEQ ID NOs:
- 1, 48, 49, 50, 51, and 6, respectively.
An isolated monoclonal antibody or antigen-binding fragment thereof comprising a heavy chain variable region having a polypeptide sequence at least 95% identical to SEQ ID NO:
- 9 and a light chain variable region having a polypeptide sequence at least 95% identical to SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.