Bispecific agonistic antibodies to il12 receptor
AssigneeDiagonal Therapeutics Inc.
InventorsAlexey Alexandrovich Lugovskoy, Jean-Christophe Hus, Melissa Geddie
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Abstract
Bispecific agonistic antibodies that bind to IL-12 receptor, and methods of using the same, are provided.
Claims36
A multi-specific binding protein comprising at least a first binding moiety which binds specifically to a human interleukin-12 receptor β1 (IL-12Rβ1) subunit, and at least a second binding moiety which binds specifically to a human IL-12 receptor β2 (IL-12Rβ2) subunit, wherein the second binding moiety exhibits higher binding affinity (KD) for the human IL-12Rβ2 subunit than the first binding moiety exhibits for the human IL-12Rβ1 subunit, and is capable of inducing IL-12 receptor signaling by inducing proximity between the IL-12Rβ1 and IL-12Rβ2 subunits of human IL-12 receptor.
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A multi-specific binding protein comprising at least a first binding moiety which binds specifically to a human interleukin-12 receptor β1 (IL-12Rβ1) subunit, and at least a second binding moiety which binds specifically to a human IL-12 receptor β2 (IL-12Rβ2) subunit, wherein:
- a) the first binding moiety comprises:
- i) a HCDR1 amino acid sequence, a HCDR2 amino acid sequence, and a HCDR3 amino acid sequence disclosed in Tables 1, 3, 4, 5, or 11;
- ii) a LCDR1 amino acid sequence, a LCDR1 amino acid sequence, and a LCDR3 amino acid sequence disclosed in Tables 2, 3, or 11;
- and
- b) the second binding moiety comprises:
- i) a HCDR1 amino acid sequence, a HCDR2 amino acid sequence, and a HCDR3 amino acid sequence disclosed in Tables 6, 8, 9, 10, or 11;
- ii) a LCDR1 amino acid sequence, a LCDR1 amino acid sequence, and a LCDR3 amino acid sequence disclosed in Tables 7, 8, or 11.
Dependencies are inferred from the claim text.