Smo human antibody
AssigneesBiocomplete Inc., Korea University Research and Business Foundaiton
InventorsBo Ram KIM, Minkyu HUR, Haet Nim LIM, Jisun LEE, Sang Cheul OH, Sang Taek JUNG
Life of this patent
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Abstract
The present disclosure relates to a novel human antibody or an antigen-binding fragment thereof that recognizes the SMO (smoothened) protein as an antigen and binds specifically thereto. The antibody of the present disclosure binds specifically to the SMO protein, which is directly involved in major cancer progression processes such as proliferation, migration, invasion and metastasis of cancer cells, and blocks the progression those processes. Therefore, it can be usefully used as a therapeutic agent for various cancers such as colon cancer, etc., resistant cancer, metastatic cancer, or recurrent cancer.
Claims21
1-24. (canceled)
A monoclonal antibody or an antigen-binding fragment thereof that recognizes the SMO (smoothened) protein as an antigen and binds specifically thereto, comprising CDRH1 of SEQ ID NO:
- 1;
- CDRH2 of SEQ ID NO:
- 2;
- CDRH3 having an amino acid sequence represented by the following General Formula 1;
- CDRL1 of SEQ ID NO:
- 4;
- CDRL2 of SEQ ID NO:
- 5;
- and CDRL3 having an amino acid sequence represented by the following General Formula 2:
- A-R-R-A-H-X1-X2-X3-G-S-X4-X5-N-P-S-W-Y-X6-D-L;
- General Formula 1
- Q-Q-G-Y-S-X7-P-R-T;
- General Formula 2
- wherein, in General Formula 1, X1 is Y or H, X2 is Y or L, X3 is G or D, X4 is T or N, X5 is Y or F, and X6 is F or V, and, in General Formula 2, X7 is S or P.
A monoclonal antibody or an antigen-binding fragment thereof that recognizes the SMO (smoothened) protein as an antigen and binds specifically thereto, comprising CDRH1 of SEQ ID NO:
- 14;
- CDRH2 of SEQ ID NO:
- 15;
- CDRH3 of SEQ ID NO:
- 16;
- CDRL1 of SEQ ID NO:
- 17;
- CDRL2 of SEQ ID NO:
- 18;
- and CDRL3 of SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.