Methods, compositions, and kits for modifying immune cell activity via kir2dl5
AssigneeAlbert Einstein College of Medicine
InventorsXingxing ZANG, Xiaoxin REN, Yao WEI
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Abstract
Provided herein are methods of modifying immune cell activity by altering KJR2DL5 expression and/or activity. The methods, which include administering to a subject one or more agents that decrease KJR2DL5 expression and/or activity, increase immune cell function, and treat diseases such as cancer and infectious diseases.
Claims44
A method of increasing immune cell function in a subject comprising administering to the subject one or more agents that decrease KIR2DL5 expression and/or activity.
A method of treating an infectious disease in a subject in need thereof comprising administering to the subject one or more agents that decrease KIR2DL5 expression and/or activity.
A method of treating cancer in a subject in need thereof comprising administering one or more agents that decrease KIR2DL5 expression and/or activity.
A method of decreasing immune cell function in a subject comprising administering to the subject one or more agents that increase KIR2DL5 expression and/or activity.
A method of treating an autoimmune disease in a subject comprising administering to the subject one or more agents that increase KIR2DL5 expression and/or activity to the subject.
A method of decreasing transplant rejection in a subject comprising administering to the subject one or more agents that increase KIR2DL5 expression and/or activity to the subject.
Dependencies are inferred from the claim text.