Cell-binding proteins and methods of use
AssigneeMablytics, Inc.
InventorsAnthony Clark Stevens, Eric Richard SJOBERG
Life of this patent
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Abstract
Embodiments of the present disclosure provide antibodies binding to sialic acid binding-immunoglobulin type lectin (siglec) proteins. Also provided are methods of treating and diagnosing cancer using such antibodies.
Claims31
An antibody, wherein the antibody binds a sialic acid binding-immunoglobulin type lectin (siglec) and wherein the antibody comprises at least one human antibody variable domain.
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A method of treating a subject with cancer, the method comprising administering an anti-siglec12 antibody to the subject, the anti-siglec12 antibody comprising:
- a heavy chain variable domain (VH) comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-7;
- and
- a light chain variable domain (VL) comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 8-14.
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Dependencies are inferred from the claim text.