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US 2025/0019418 A1Published application
Systems and methods for the production of methemoglobin and its derivatives
AssigneesOhio State Innovation Foundation, The Regents of the University of California
InventorsAndre PALMER, Pedro J. CABRALES AREVALO, Xiangming GU
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for producing methemoglobin or polymerized methemoglobin. Also provided are pharmaceutical compositions comprising methemoglobin complexed with haptoglobin or polymerized methemoglobin, as well as methods of using thereof to treat cyanide and hydrogen sulfide poisoning.
Claims33
A method for preparing methemoglobin or polymerized methemoglobin, the method comprising:
- (i) contacting a solution comprising ferrous hemoglobin or polymerized ferrous hemoglobin with an oxidizing agent under conditions effective to produce a solution comprising methemoglobin or polymerized methemoglobin;
- and
- (ii) filtering the solution comprising methemoglobin or polymerized methemoglobin by ultrafiltration against a filtration membrane having a pore size that separates the protein from the oxidization agent and reaction byproducts, thereby forming a retentate fraction comprising the methemoglobin or polymerized methemoglobin and a permeate fraction comprising impurities.
Dependencies are inferred from the claim text.