A Composition and A Method of Rejuvenating DNA and Preventing DNA Damage
AssigneeChulalongkorn University
InventorApiwat MUTIRANGURA
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Abstract
The present disclosure relates to a method for rejuvenating DNA and/or preventing DNA damage within a nucleus of a cell. The method generally comprises administering a reagent having a vector containing a polynucleotide sequence as setting forth in SEQ ID No. I or SEQ ID No. 2 encoding for a peptide into the cell, the vector being configured to express the encoded peptide within the cell; and overexpressing the encoding encoded peptides, wherein the overexpressed peptides form one or more complexes, within the cell, capable of rejuvenating DNA and preventing damage of DNA in the nucleus of the cell.
Claims6
1-9. (canceled)
A vector capable of expressing a peptide in cells for preventing damage of DNA in a nucleus of the cells, the vector comprising a polynucleotide sequence as setting forth in SEQ ID No. 1 encoding for the peptide, wherein the peptide is configured to increase production of Phy-RIND-EDSBs in the nucleus.
A method for rejuvenating DNA and/or preventing DNA damage within a nucleus of cells, the method comprising:
- transfecting the cells with a vector containing a polynucleotide sequence as setting forth in SEQ ID No. 1 encoding for the peptide into the cells, the vector being configured to express the encoded peptide within the cells subsequent to the transfecting step;
- and
- producing Phy-RIND-EDSBs in the nucleus of the cells for prevention of DNA damage, wherein the cells are aging cells with Youth-DNA-GAPs lower than 0.3% EDSB PCR of a control and/or an accumulation of senescence-associated β-galactosidase cells more than 50%.
Dependencies are inferred from the claim text.