Peptide Activating Agent
AssigneeInterk Peptide Therapeutics Limited
InventorMichael Agrez
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Abstract
The present invention is related to compositions and methods for activating Lck, including in vivo, in vitro and ex vivo uses.
Claims27
A peptide for activating Lck, wherein the peptide comprises a Lck activating polypeptide moiety of Formula I or an inverted sequence thereof:
- R/K′-x1-R/K-x2-R/K-x3-x4-x5-x6-R/K″ Formula I
- wherein:
- each R/K is independently an arginine or lysine amino acid residue;
- R/K′ is an arginine or lysine amino acid residue and is present or absent;
- R/K″ is an arginine or lysine amino acid residue and is present or absent;
- x1 to x6 are each independently an amino acid;
- and
- wherein amino acids x3 to x6 are collectively present or absent, and R/K″ is absent when amino acids x3 to x6 are absent.
A peptide comprising an amino acid sequence selected from the group consisting of RSKAKNPLYR-(2Adod)4, rskaknplyr-(2Adod)4, RVKVKVVVVR-(2Adod)4, and rvkvkvvvvr-(2Adod)4.
A peptide consisting of an amino acid sequence selected from the group consisting of RSKAKNPLYR-(2Adod)4, rskaknplyr-(2Adod)4, RVKVKVVVVR-(2Adod)4, and rvkvkvvvvr-(2Adod)4.
Dependencies are inferred from the claim text.