Bicyclic heterocyclic compounds for prophylaxis andtreatment of viral infections

A compound having the structure of

• (a) wherein A″ are independently an unsubstituted heterocyclic group or a substituted heterocyclic group;
• (b) wherein X′ is a carbon or a nitrogen;
• (c) wherein L′, M′, L″, and M″ are independently a carbon or a nitrogen;
• (d) wherein P1′, P1″, and G1′ are independently CR20 or NR21, and R20 and R21 are independently absent, a hydrogen, a halogen, a nitrile group, a nitro group, an oxo group, an ester group, an unsubstituted aliphatic ester group, a substituted aliphatic ester group, an ether group, an unsubstituted aliphatic ether group, a substituted aliphatic ether group, an unsubstituted amino group, a substituted amino group, an unsubstituted aliphatic amino group, a substituted aliphatic amino group, an amide group, an aliphatic-amide group, an azide group, an unsubstituted aliphatic group, a substituted aliphatic group, an unsubstituted aryl group, a substituted aryl group, an unsubstituted aryl-aliphatic group, a substituted aryl-aliphatic group, an unsubstituted heterocyclic group, a substituted heterocyclic group, an unsubstituted heterocyclic-aliphatic group, or a substituted heterocyclic-aliphatic group;
• (e) wherein R2 and R2′ are independently absent, a hydrogen, an unsubstituted aliphatic group, a substituted aliphatic group, an unsubstituted aryl group, a substituted aryl group, an unsubstituted aryl-aliphatic group, a substituted aryl-aliphatic group, an unsubstituted aliphatic ether group, or a substituted aliphatic ether group;
• (f) wherein R3′″ and R3″″ are independently absent, a hydrogen, an unsubstituted aliphatic group, a substituted aliphatic group, an unsubstituted amide group, a substituted amide group, an unsubstituted aliphatic ester group, a substituted aliphatic ester group, an unsubstituted aliphatic ether group, a substituted aliphatic ether group, an unsubstituted heterocyclic group, a substituted heterocyclic group, an unsubstituted heterocyclic-aliphatic group, or a substituted heterocyclic-aliphatic group;
• (g) A″ is
• (gi) wherein is a carbon or a nitrogen,
• (gii) wherein E2′, E2″, G2′, G2″, Q2′, Q2″, and W2′ are independently an oxygen, a sulfur, CR20, or NR21, and R20 and R21 are independently absent, a hydrogen, a halogen, a nitrile group, a nitro group, an oxo group, an ester group, an unsubstituted aliphatic ester group, a substituted aliphatic ester group, an ether group, an unsubstituted aliphatic ether group, a substituted aliphatic ether group, an unsubstituted amino group, a substituted amino group, an unsubstituted aliphatic amino group, a substituted aliphatic amino group, an amide group, an unsubstituted aliphatic-amide group, a substituted aliphatic-amide group, an azide group, an unsubstituted aliphatic group, a substituted aliphatic group, an unsubstituted aryl group, a substituted aryl group, an unsubstituted aryl-aliphatic group, a substituted aryl-aliphatic group, an unsubstituted heterocyclic group, a substituted heterocyclic group, an unsubstituted heterocyclic-aliphatic group, or a substituted heterocyclic-aliphatic group,
• (giii) wherein Q1′ and Q1″ are carbon;
• and
• (h) wherein the substituents are independently a phosphoramidate, a heterocyclic group, a halogen, a sulfonic acid, an azide group, a cyanate group, an isocyanate group, a nitrate group, a nitrile group, an isonitrile group, a nitrosooxy group, a nitroso group, a nitro group, an aldehyde group, an alkoxy group, an acyl halide group, a carboxylic acid group, a carboxylate group, an alkyl group, a heteroalkyl group, an alkenyl group, a heteroalkenyl group, an alkynyl group, a heteroalkynyl group, an aryl group, a heteroaryl group, polyaryl group, a heteropoly aryl group, a alkyl aryl group, an amino group, an ester group, a hydroxyl group, a thiol group, a sulfonyl group, an ester group, an aliphatic ester group, an amide group, an aliphatic amide group, an azo group, an acyl group, a carbonyl group, a carbonate ester group, an ether group, an aminooxy group, or a hydroxyamino group.