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US 2025/0019388 A1Published application
Stat3 degraders and uses thereof
AssigneeKymera Therapeutics, Inc.
InventorsSagar Agarwal, Christopher De Savi, Joyoti Dey, Vaishali Dixit, Bradley Enerson, Ashwin Gollerkeri, Jared Gollob, Chris Ho, Michele Mayo, Haojing Rong, Bin Yang
Life of this patent
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Abstract
The present invention relates to STAT3 degraders, their liquid formulations, and methods of use thereof for treating cancer.
Claims19
A liquid formulation comprising Compound A, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient and/or carrier:
- wherein Compound A is (2-(((5S,8S,10aR)-3-acetyl-8-(((S)-5-amino-1-(2-chloro-3-(4-(((S)-1-((2S, 4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl) amino)-4-oxobutyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-6-oxodecahydropyrrolo [1,2-a][1,5]diazocin-5-yl)carbamoyl)-1H-indole-5-carbonyl)phosphonic acid.
Dependencies are inferred from the claim text.