Spirocyclic annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

A compound of the formula (I)

• wherein
• R1a and R1b are both independently selected from the group consisting of hydrogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, halogen, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2, C3-5cycloalkyl and 3-5 membered heterocyclyl;
• R2a and R2b are both independently selected from the group consisting of hydrogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, halogen, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2, C3-5cycloalkyl and 3-5 membered heterocyclyl;
• and/or, optionally, one of R1a or R1b and one of R2a or R2b together with the carbon atoms they are attached to form a cyclopropane ring;
• Z is —(CR6aR6b)n—;
• each R6a and R6b is independently selected from the group consisting of hydrogen, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, halogen, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2, C3-5cycloalkyl and 3-5 membered heterocyclyl;
• or R6a and R6b together with the carbon atom they are attached to form a cyclopropane ring;
• n is selected from the group consisting of 0, 1 and 2;
• or
• Z is sulphur (—S—);
• ring B is a ring selected from the group consisting of C3-13alicycle, C6-10arene, 3-13 membered heterocycle and 5-6 membered heteroarene;
• each R3, if present, is independently selected from the group consisting of R7 and R8;
• each R7 is independently selected from the group consisting of —OR8, —NR8R8, halogen, —CN, —C(═O)R8, —C(═O)OR8, —C(═O)NR8R8, —NHC(═O)OR8 and the bivalent substituent ═O;
• each R8 is independently selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkoxy, C1-6 haloalkyl, C3-10cycloalkyl, 3-11 membered heterocyclyl, wherein the C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C3-10cycloalkyl and 3-11 membered heterocyclyl, are all optionally substituted with one or more, identical or different R9 and/or R10;
• each R9 is independently selected from the group consisting of —OH, halogen and C1-6alkoxy;
• each R10 is independently selected from the group consisting of C1-6alkyl and 3-11 membered heterocyclyl;
• q is selected from the group consisting of 0, 1, 2, 3 and 4;
• W is nitrogen (—N═) or —CH═;
• V is nitrogen (—N═) or —CH═;
• ring A is a ring selected from the group consisting of pyrrole, furan, thiophene, imidazole, pyrazole, oxazole, isoxazole, thiazole, isothiazole and triazole;
• each R4, if present, is independently selected from the group consisting of C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6haloalkoxy, cyano-C1-6alkyl, halogen, —OH, —NH2, —NH(C1-4alkyl), —N(C1-4alkyl)2, —CN, C3-5cycloalkyl and 3-5 membered heterocyclyl;
• p is selected from the group consisting of 0, 1, 2 and 3;
• R5 is a 3-11 membered heterocyclyl optionally substituted with one or more identical or different substituent selected from the group consisting of C1-6alkyl, C1-6alkoxy and 5-6 membered heterocyclyl, wherein the C1-6alkyl is optionally substituted with cyclopropyl;
• or
• R5 is —O—C1-6alkyl substituted with a 3-11 membered heterocyclyl, wherein the 3-11 membered heterocyclyl is optionally substituted with one or more, identical or different R11 and wherein the —O—C1-6alkyl is optionally substituted on one carbon by replacing two hydrogen to form a C3-6alicycle;
• each R11 is independently selected from the group consisting of C1-6alkyl, C1-6alkoxy, halogen, C3-10cycloalkyl and 3-11 membered heterocyclyl;
• or a salt thereof.