Benzofuran salt morphic forms and mixtures for the treatment of mental disorders or mental enhancement
AssigneeTactogen Inc
InventorsMatthew J. Baggott, Sean Jeffrey Lofthus, Xanthe Marie Renomeron De Leon, Aniruddh Singh, Connor James Hudgins
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Abstract
Salt morphic forms, morphic salt mixtures, and specified salt mixtures of pharmaceutically active benzofuran compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes salt morphic forms, morphic salt mixtures, and specified salt mixtures of benzofuran compounds, compositions thereof, and methods for generally modulating central nervous system activity and treating central nervous system disorders.
Claims19
A crystalline compound of structure:
- which is an HCl salt and is characterized by an X-ray powder diffraction (XRPD) pattern comprising at least four 2theta values selected from 13.2, 15.1, 16.9, 17.9, 19.2, 20.8, 22.5, 24.4, 25.4, 25.8, 26.2, 27.6, and 31.6±0.4° 2theta.
A crystalline compound of structure:
- which is an HCl salt and is characterized by an X-ray powder diffraction (XRPD) pattern comprising at least four 2theta values selected from 6.7, 12.7, 13.4, 15.8, 19.0, 19.6, 21.2, 24.7, 25.1, 26.1, 26.8, 28.1, 29.0, 30.4, 31.1, and 39.7±0.4° 2theta.
A method of treating a central nervous system disorder comprising administering to a host in need thereof, an effective amount of a crystalline compound of structure:
- which is an HCl salt and is characterized by an X-ray powder diffraction (XRPD) pattern comprising at least four 2theta values selected from 13.2, 15.1, 16.9, 17.9, 19.2, 20.8, 22.5, 24.4, 25.4, 25.8, 26.2, 27.6, and 31.6±0.4° 2theta;
- or an effective amount of a crystalline compound of structure:
- which is an HCl salt and is characterized by an X-ray powder diffraction (XRPD) pattern comprising at least four 2theta values selected from 6.7, 12.7, 13.4, 15.8, 19.0, 19.6, 21.2, 24.7, 25.1, 26.1, 26.8, 28.1, 29.0, 30.4, 31.1, and 39.7±0.4° 2theta.
Dependencies are inferred from the claim text.