Compounds
AssigneeInflazome Limited
InventorsMatthew COOPER, David MILLER, Angus MACLEOD
Life of this patent
Estimating the term…
Abstract
The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted with a monovalent group comprising either (i) an aryl or a heteroaryl group, or (ii) a nitrogen-containing heterocyclic group, and wherein the group attached to the terminal nitrogen atom of the urea group is a 6-membered cyclic group substituted at the 2- and 4-positions. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.
Claims21
1-28. (canceled)
A compound of formula (I):
- or a pharmaceutically acceptable salt or solvate thereof, wherein:
- Q is selected from O or S;
- R1 is a monovalent group comprising an aryl or a heteroaryl group;
- R2 is a fused phenyl or a fused 6-membered heteroaryl group, wherein a cycloalkyl, cycloalkenyl, non-aromatic heterocyclic, aryl or heteroaryl ring is fused to the phenyl or the 6-membered heteroaryl group across the 2,3-positions, relative to the point of attachment of the phenyl or the 6-membered heteroaryl group to the remainder of the molecule, wherein the phenyl or the 6-membered heteroaryl group is further substituted at the 4-position, and wherein R2 may optionally be further substituted;
- m is 0, 1, 2, 3 or 4;
- each R3 is independently a halo, —OH, —NO2, —NH2, —N3, —SH, —SO2H, —SO2NH, or a saturated or unsaturated hydrocarbyl group, wherein the hydrocarbyl group may be straight-chained or branched, or be or include cyclic groups, wherein the hydrocarbyl group may optionally be substituted, and wherein the hydrocarbyl group may optionally include one or more heteroatoms N, O or S in its carbon skeleton;
- and
- wherein optionally any R3, and any two adjacent carbon atoms of ring A, may together form a 4- to 12-membered saturated or unsaturated cyclic group fused to ring A, wherein the cyclic group fused to ring A may optionally be substituted.
Dependencies are inferred from the claim text.