Benzothia(di)azepine compounds and their use as bile acid modulators

A method for treating a disease or disorder in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I)

• wherein
• M is selected from —CH2— and —NR6—;
• R1 is C1-4 alkyl;
• R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, cyano, nitro, amino, N-(C1-4 alkyl)amino, N,N-di(C1-4 alkyl)amino, N-(aryl-C1-4 alkyl)amino, C1-6 alkylcarbonylamino, C3-6 cycloalkylcarbonylamino, N-(C1-4 alkyl)aminocarbonyl, N,N-di(C1-4 alkyl)aminocarbonyl, C1-4 alkyloxycarbonylamino, C3-6 cycloalkyloxycarbonylamino, C1-4 alkylsulfonamido and C3-6 cycloalkylsulfonamido;
• n is an integer 1, 2 or 3;
• R3 is selected from the group consisting of hydrogen, halogen, cyano, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C3-6 cycloalkyloxy, C1-4 alkylthio, C3-6 cycloalkylthio, amino, N-(C1-4 alkyl)amino and N,N-di(C1-4 alkyl)amino;
• one of R4 and R5 is carboxyl, and the other of R4 and R5 is selected from the group consisting of hydrogen, fluoro, C1-4 alkyl and C1-4 haloalkyl;
• R6 is selected from the group consisting of hydrogen and C1-4 alkyl;
• and
• R7 is selected from the group consisting of hydrogen and C1-4 alkyl;
• or a pharmaceutically acceptable salt thereof,
• wherein the disease or disorder is selected from the group consisting of:
• a cardiovascular disease;
• a disorder of fatty acid metabolism;
• a glucose utilization disorder;
• a gastrointestinal disease or disorder;
• a hyperabsorption syndrome;
• hypervitaminosis and osteopetrosis;
• hypertension;
• glomerular hyperfiltration;
• and pruritus of renal failure.