Compounds and method of use thereof for treating bacterial diseases
AssigneesPeking University, Institute of Genetics and Developental Biology, Chinese Academy of Sciences
InventorsXiaoguang LEI, Jian-Min Zhou, Haijun Wang, Pei Miao, Wei Wang
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compounds that can inhibit the type III secretion system (TTSS) to decrease the pathogenesis of gram-negative bacteria. These compounds may have wide applications for treating bacteria diseases caused by gram-negative bacteria in a host species, including but not limited to, plants and animals. The present invention further relates to compositions that inhibit pathogenesis of gram-negative bacteria without killing the bacteria. Methods relating to preventing and/or treating infection of a host species by bacterial pathogens are also provided herein.
Claims21
1-30. (canceled)
A compound, or a stereoisomer or tautomer thereof, or a salt of any of the foregoing, wherein the compound is selected from the group consisting of:
- or a stereoisomer or tautomer thereof, or a salt of any of the foregoing.
A compound of formula (IA), or a stereoisomer or tautomer thereof, or a salt of any of the foregoing,
- wherein:
- B is phenylene;
- u and v are each independently an integer of at least 1.
Dependencies are inferred from the claim text.