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AssigneeCornell University
InventorsMelik Z. Turker, Thomas C. Gardinier, II, Ulrich B. Wiesner, Kai Ma
Estimating the term…
Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.
A silica nanoring defining a single aperture and comprising an outer surface and an inner surface, wherein at least a portion of or substantially all of the outer surface, and optionally, at least a portion of or substantially all of the inner surface, or all of the surfaces of the silica nanoring are functionalized with polyethylene glycol (peg) groups, functionalized peg groups, or a combination thereof, and at least a portion of or all the silica matrix of the silica nanoring is microporous.
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A method of making silica nanorings comprising
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The method of claim 25, further comprising utilizing gel permeation chromatography (GPC) and/or utilizing fluorescence correlation spectroscopy (FCS) to determine the number of display groups and/or silica nanorings.
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Dependencies are inferred from the claim text.