Furanocoumarins free bakuchiol compositions and their method of preparation thereof

A process of isolating pure bakuchiol (not less than 99% w/w) as represented in STR #1, substantially free of furanocoumarins from Psoralea sp., comprising steps of:

• a) Powdering Psoralea sp. plant parts and pulverizing using 1.5 mm mesh and passing through magnetic separator to obtain a coarse powder;
• b) Subjecting the enriched extract of step b) to super critical fluid extraction (SCFE) using liquid CO2 in the presence of an entrainer and a stabilizing agent to obtain two fractions:
• low volatile compounds—S1 fraction, high volatile compounds—S2 fraction and a spent material (residue);
• c) Identifying the compounds in low volatile and high volatile fractions of step b) as bakuchiol, wherein the total yield of bakuchiol in S1 fraction is 5-15% w/w and 0.5-3% w/w in S2 fraction;
• d) Pooling the S1 and S2 fractions from step b) to obtain bakuchiol enriched extract, substantially free of furanocoumarins;
• e) Subjecting the bakuchiol enriched extract of step d) to high vacuum distillation (HVD) at desired temperature with vacuum to obtain different bakuchiol enriched fractions and a pot residue, wherein the bakuchiol content is assayed using HPLC;
• f) Pooling the bakuchiol enriched fractions of step e) and passing them through a Silica gel column prepacked with heptane and eluting using a suitable mobile phase and collecting different fractions to get obtain content of bakuchiol (99% w/w) as assayed by HPLC;
• and
• g) Collecting the fractions with bakuchiol content of not less than 99% w/w and further subjecting the fractions to Thin Layer chromatography with suitable solvents as mobile phase with detection under wavelength UV 254 nm, to obtain bakuchiol free or substantially free of furanocoumarins