Endovascular nerve tissue stimulation therapy

A system comprising:

• processing circuitry;
• and
• an endovascular device comprising:
• an expandable substrate configured to be delivered endovascularly to a trial therapy delivery location in a patient;
• one or more first electrodes positioned on the expandable substrate, wherein the one or more first electrodes are configured to deliver nerve tissue stimulation trial therapy to a target nerve tissue of the patient;
• and
• one or more second electrodes positioned on the expandable substrate, wherein the one or more second electrodes are configured to sense one or more activation signals of the target nerve tissue,
• wherein the processing circuitry is configured to:
• in response to delivery of the nerve tissue stimulation trial therapy to the target nerve tissue via the one or more first electrodes at the trial therapy delivery location, receive, via the one or more second electrodes, the one or more sensed activation signals;
• determine whether activation of the target nerve tissue at the trial therapy delivery location satisfies a target nerve tissue activation threshold based on the one or more sensed activation signals;
• in response to determining that the activation of the target nerve tissue at the trial therapy delivery location satisfies the target nerve tissue activation threshold based on the one or more sensed activation signals, generate a first indication that the trial therapy delivery location of at least one of the first electrodes is acceptable to deliver nerve tissue stimulation therapy;
• and
• in response to determining that the activation of the target nerve tissue at the trial therapy delivery location does not satisfy the target nerve tissue activation threshold based on the one or more sensed activation signals, generate a second indication that the trial therapy delivery location of the first electrodes is not acceptable to deliver nerve tissue stimulation therapy.