Multimodal treatment of alzheimer's disease
OwnerYossi GROSS, Ofri VAISMANinventors
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Abstract
A method is provided that includes non-invasively applying a first non-invasive sphenopalatine ganglion (SPG)-stimulation electrode to a first SPG-stimulation site of a subject on an external surface of skin between a mandibular notch and a zygomatic process of a temporal bone, the subject identified as at risk of or suffering from dementia. A second SPG-stimulation electrode is applied to a second SPG-stimulation site of the subject. Cerebral blood flow (CBF) of the subject is increased by activating circuitry to drive, between the first non-invasive SPG-stimulation electrode and the second SPG-stimulation electrode, alternating current configured to stimulate an SPG of the subject. Other embodiments are also described.
Claims27
1-5. (canceled)
The method according to claim 28, wherein activating the circuitry comprises activating the circuitry to drive the alternating current in pulses having a pulse width of 50-5,000 microseconds and a frequency of 10-40 Hz.
The method according to claim 28, wherein activating the circuitry comprises activating the circuitry to drive the alternating current at a frequency of 10-40 Hz.
The method according to claim 28, wherein activating the circuitry comprises activating the circuitry to drive the alternating current in pulses having a pulse width of 50-5,000 microseconds.
(canceled)
The method according to claim 30,
- wherein an oral support is coupled to the second SPG-stimulation electrode, and
- wherein non-invasively applying the second SPG-stimulation electrode to the second SPG-stimulation site comprises placing the oral support within the oral cavity such that the oral support non-invasively applies the second SPG-stimulation electrode to the second SPG-stimulation site.
The method according to claim 30,
- wherein the method further comprises minimally invasively inserting a wire, including both ends thereof, into a greater palatine canal via the greater palatine foramen, and
- wherein placing the second SPG-stimulation electrode in the oral cavity in the vicinity of the greater palatine foramen comprises placing the second SPG-stimulation electrode in the oral cavity in the vicinity of the greater palatine foramen, such that the second SPG-stimulation electrode is separated from the wire by masticatory mucosa.
The method according to claim 30, wherein the first SPG-stimulation site and the greater palatine foramen are ipsilateral.
The method according to claim 28, wherein non-invasively applying the first non-invasive SPG-stimulation electrode to the first SPG-stimulation site comprises coupling a head support to a head of the subject such that the head support non-invasively applies the first non-invasive SPG-stimulation electrode to the first SPG-stimulation site.
(canceled)
22-27. (canceled)
A method comprising:
- non-invasively applying:
- a first non-invasive sphenopalatine ganglion (SPG)-stimulation electrode to an external surface of skin of a head of a subject at a first SPG-stimulation site, and
- a second non-invasive SPG-stimulation electrode at a second SPG-stimulation site of the subject, such that a line between the first and the second SPG-stimulation sites passes within 1 cm of an SPG of the subject;
- and
- increasing cerebral blood flow (CBF) of the subject by activating circuitry to drive, between the first and the second non-invasive SPG-stimulation electrodes, alternating current configured to stimulate the SPG.
Dependencies are inferred from the claim text.