Compositions and methods for tissue repair
AssigneesWashington University, The Trustees of Columbia University in the City of New York, ACatechol, Inc.
InventorsGuy GENIN, Stavros THOMOPOULOS, Fei FANG, Kollbe AHN, Roscoe LINSTADT
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Abstract
Among the various aspects of the present disclosure is the provision of compositions and methods for tissue defect repairs. In some embodiments, the biocompatible adhesive, biocompatible film, or biocompatible material comprises an oxidized chitosan or crosslinked chitosan. In some embodiments, the oxidizing agent or crosslinking agent has been removed to maintain biocompatibility.
Claims23
A biocompatible adhesive for use in a subject having a tissue defect, wherein the biocompatible adhesive comprises an oxidized or crosslinked chitosan and optionally does not comprise an oxidizing agent or crosslinking agent.
A method of generating a biocompatible film, biocompatible adhesive, or biocompatible material comprising:
- removing an oxidizer in an oxidized chitosan, resulting in a substantially oxidizer-free oxidized chitosan biocompatible adhesive;
- and
- optionally drying the biocompatible adhesive resulting in a biocompatible film or applying the biocompatible adhesive to the biocompatible film.
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Dependencies are inferred from the claim text.