Liquid radioembolic agents and related embolization systems and methods of embolization

An embolization kit for delivering local radiation to a tumor while also causing tumor devascularization due to embolization, the kit comprising:

• a first liquid radioembolic agent for treatment of at least a first region of the tumor, the first liquid radioembolic agent comprising:
• a biocompatible polymer or prepolymer;
• a first radioisotope having a first type of ionizing radiation for treatment of the first region of the tumor;
• and
• a second liquid radioembolic agent for treatment of at least a second region of the tumor, the second liquid radioembolic agent comprising:
• a biocompatible polymer or prepolymer;
• a second radioisotope having a second type of ionizing radiation for treatment of the second region of the tumor, the second type of ionizing radiation being different than the first type of ionizing radiation;
• wherein each of the first type of ionizing radiation and the second type of ionizing radiation is selected from the group consisting of:
• alpha type ionizing radiation, beta type ionizing radiation;
• gamma type ionizing radiation;
• and combinations thereof.

A method for embolizing a blood vessel leading to or in a solid mass tumor and causing necrosis to a portion of the solid mass tumor, the method comprising the steps of:

• identifying at least one blood vessel that leads to or is in the solid mass tumor;
• injecting a first liquid radioembolic agent into the at least one blood vessel, the first liquid radioembolic agent including a biocompatible polymer or prepolymer and a first radioisotope and being injected into the blood vessel under conditions wherein the polymer or prepolymer polymerizes and forms a solid mass which embolizes the at least one blood vessel and further wherein the first radioisotope is employed in an amount effective to cause necrosis of at least a first portion of the tumor;
• and
• injecting a second liquid radioembolic agent into the at least one blood vessel, the second liquid radioembolic agent including a biocompatible polymer or prepolymer and a second radioisotope and being injected into the blood vessel under conditions wherein the polymer or prepolymer polymerizes and forms a solid mass which embolizes the at least one blood vessel and further wherein the second radioisotope is employed in an amount effective to cause necrosis of at least a second portion of the tumor.

A method for treatment of a target tissue comprising the steps of:

• identifying at least one first blood vessel that leads to or is in the target tissue;
• injecting a first liquid radioembolic agent into the at least one blood vessel, the first liquid radioembolic agent including a biocompatible polymer or prepolymer and a first radioisotope and being injected into the at least one first blood vessel under conditions wherein the polymer or prepolymer polymerizes and forms a solid mass which embolizes the at least one first blood vessel and further wherein the first radioisotope is employed in an amount effective to cause necrosis of at least a first portion of the target tissue;
• and
• injecting a second liquid radioembolic agent into the at least one first blood vessel or into at least one second blood vessel, the second liquid radioembolic agent including a biocompatible polymer or prepolymer and a second radioisotope and being injected into the at least one first blood vessel or the at least one second blood vessel under conditions wherein the polymer or prepolymer polymerizes and forms a solid mass which embolizes the at least one first blood vessel or the at least one second blood vessel and further wherein the second radioisotope is employed in an amount effective to cause necrosis of at least a second portion of the target tissue.