Hafnium (iv) oxide nanoparticles and aqueous compositions thereof
AssigneesUniversitäT Basel, Universiteit Gent
InventorsLoren DEBLOCK, Jonathan DE ROO
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Abstract
The invention relates to a hafnium (IV) oxide (HfO2) nanoparticle nanocrystal comprising or having a diameter equal or less than (≤) 15 nm, stabilized by a plurality of dispersant molecules attached to its surface. The dispersant molecules comprise of a catechol or gallol surface adsorption moiety and an oligo (ethyleneglycol) moiety. The invention further relates to a composition of such nanoparticles in stable colloidal suspension at physiological pH, and the use of the composition in medical treatment and diagnostic applications, particularly to enhance radiotherapy and as an X ray contrast agent. In yet another aspect, the invention provides a method for manufacturing compositions and nanoparticles according to the invention.
Claims17
A nanoparticle comprising
- a. a nanocrystal comprising or essentially consisting of hafnium (IV) oxide (HfO2) having a diameter equal or less than (≤) 15 nm, and
- b. a plurality of dispersant molecules attached to the surface of said nanocrystal, wherein each of the dispersant molecules comprises or essentially consists of
- i. a surface adsorption moiety selected from the group comprising a catechol or a gallol, particularly a 1,2-hydroxy-4-nitrophenyl moiety;
- and
- ii. an oligo (ethyleneglycol) moiety.
Dependencies are inferred from the claim text.