High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
AssigneeThe Brd. of Trustees of the Univ. of Illinois
InventorsKing C. Li, Jeffrey S. Moore
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Abstract
Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.
Claims19
A method of triggering a change in a biological activity of a cell or tissue comprising contacting a composition comprising a chromogenic or luminescent mechanophore covalently linked to a gel or elastomer matrix, wherein the chromogenic or luminescent mechanophore is present in the gel or elastomer matrix at about 1.0 wt % to about 5 wt %, with the cell or tissue or bringing the composition into the vicinity of the cell or tissue, and subjecting the composition to high intensity focused ultrasound such that a light emission or chromogenic change is produced from the mechanophore, wherein the light emission or chromogenic change triggers a change in the biological activity of the cell or tissue.
A method for remotely and non-invasively activating a mechanophore in the vicinity of a cell, cell culture, tissue, or patient comprising:
- (a) implanting a composition comprising a chromogenic or luminescent mechanophore covalently linked to a gel or elastomer matrix, wherein the chromogenic or luminescent mechanophore is present in the gel or elastomer matrix at about 1.0 wt % to about 5 wt %, within the cell, cell culture, tissue, or patient;
- contacting the composition with the cell, cell culture, tissue, or patient;
- or bringing the composition into the vicinity the cell, cell culture, tissue, or patient, and
- (b) directing high intensity focused ultrasound to the composition such that the mechanophore is activated.
The method of claim 15, wherein the energy acceptor is different from the chromogenic or luminescent mechanophore.
Dependencies are inferred from the claim text.