Alpha and gamma-d polyglutamated antifolates and uses thereof
AssigneeL.E.A.F. Holdings Group LLC
InventorsClet NIYIKIZA, Victor Mandla MOYO
Life of this patent
Estimating the term…
Abstract
The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).
Claims75
A composition comprising an alpha or D-gamma polyglutamated antifolate.
The composition of any of the preceding claims, which is in unit dosage form.
The composition of any of the preceding claims, for use in the treatment of disease.
Use of the compound or the composition of any of the preceding claims, in the manufacture of a medicament for the treatment of disease.
A method for at least treating or preventing disease in a subject needing such treatment or prevention, the method comprising administering the compound or the composition of any of any of the preceding claims.
Dependencies are inferred from the claim text.