Methods of Making and Using Polyphenols Complexed With a Protein, Peptide, Amino Acid, Polysaccharide, Disaccharide, or Monosaccharide

A polyphenol complex comprising

• a therapeutically effective amount of one or more polyphenols wherein the therapeutically effective amount of one or more polyphenols is a resveratrol;
• and
• one or more complexing agents conjugated to a therapeutically effective amount of one or more polyphenols, wherein the one or more complexing agents are selected from proteins, peptides, amino acids, polysaccharides, disaccharides, monosaccharides, amino sugars, glycosaminoglycans, and glycol-proteins, disposed in a pharmaceutically acceptable excipient, diluent, or carrier.