Injectable slurries and methods of manufacturing and using the same

A method of crystallizing one or more lipids in a tissue, the method comprising:

• administering an injectable cold slurry comprising a plurality of sterile ice crystals and at least one freezing point depressant to the tissue,
• wherein administration of the injectable cold slurry causes the one or more lipids in the tissue to crystallize.

A method of crystallizing one or more lipids, the method comprising:

• administering an injectable cold slurry to a tissue comprising one or more lipids, wherein the injectable cold slurry is cooled to a temperature sufficient to form a plurality of ice crystals in the injectable cold slurry prior to administration;
• and
• allowing the injectable cold slurry to remain in contact with the tissue comprising one or more lipids for a period of time, wherein the period of time comprises a first period of heat exchange, a second period of heat exchange, and a third period of heat exchange.

A method of crystallizing one or more lipids in a target tissue, the method comprising:

• injecting an injectable cold slurry comprising a freezing point depressant and a plurality of ice crystals into the target tissue;
• wherein the injectable cold slurry remains in contact with the target tissue comprising the one or more lipids for a period of time, wherein the period of time is sufficient to allow a heat exchange between a latent heat of fusion from the plurality of ice crystals melting and a latent heat of fusion from crystallization of the one or more lipids.