Survivin targeting polypeptides for detection and treatment of cancer
AssigneeThe University of Chicago
InventorsAnthony KOSSIAKOFF, Annika SÄÄF, Marcin URA, Somnath MUKHERJEE
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Abstract
Aspects of the present disclosure are directed to survivin-targeting polypeptides, including antibodies, antibody-drug conjugates, antibody fragments, antibody-like molecules, and chimeric receptors. Also disclosed herein are nucleic acids encoding for such survivin-targeting polypeptides and cells comprising such nucleic acids. Described are methods for detection, diagnosis, and treatment of cancer using survivin-targeting polypeptides.
Claims86
An antibody or antigen binding fragment comprising a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises a HCDR1, HCDR2, and HCDR3 having at least 80% sequence identity to the HCDR1, HCR2, HCR3 from a heavy chain variable region of a clone of Table 1 and wherein the light chain variable region comprises a LCDR1, LCDR2, and LCDR3 having at least 80% sequence identity to the LCDR1, LCDR2, and LCDR3 from the light chain variable region of the same clone of Table 1.
A nucleic acid encoding a heavy chain or light chain region, wherein the nucleic acid has at least 70% sequence identity to one of SEQ ID NOS:157-207 or 346-415.
Dependencies are inferred from the claim text.