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OwnerTijana Martinov, Rachel Perret +2inventors
InventorsTijana Martinov, Rachel Perret, Philip D. Greenberg, Thomas M. Schmitt
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The present disclosure provides compositions and methods for targeting SOX2 antigen to, for example, treat or manage cancer. Provided compositions include binding proteins that are capable of binding to a SOX2 antigen:HLA complex. Also provided are polynucleotides and transgene constructs encoding binding proteins, such as a T cell receptor or a chimeric antigen receptor, that specifically bind to a SOX2 antigen. Such polynucleotides and transgene constructs can be introduced into an immune cell, such as a T cell, and used in immunotherapy in a subject having or at risk for a cancer associated with SOX2 expression or activity. The present disclosure also provides immunogenic compositions comprising SOX2 antigens, and related uses.
An isolated binding protein that is capable of binding to a SOX2 peptide antigen:HLA complex, wherein the SOX2 peptide comprises or consists of the amino acid sequence set forth in SEQ ID NO.:5, 2, 3, 4, 6, or 7, and wherein, optionally, the binding comprises specific binding.
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A method for inducing an immune response in a subject having, and/or for treating in a subject, a disease or disorder associated with expression of a SOX2 antigen comprising or consisting of the amino acid sequence according to any one of SEQ ID NOs:2-7, or with SOX2 expression or activity, the method comprising administering to the subject an effective amount of T cells that express a TCR that specifically binds to a peptide:HLA complex expressed on the surface of a target cell, wherein the peptide comprises or consists of the amino acid sequence according to any one of SEQ ID NOs:2-7, and wherein the HLA is optionally HLA-A*02:01.
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Dependencies are inferred from the claim text.