Treatment of interferon driven inflammation
AssigneeThe Provost, Fellows, Foundation Scholars and the other members of Board, of the College of the Holy
InventorsLuke O’Neill, Christian Peace, Alexander Hooftman, Dylan Ryan
Life of this patent
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Abstract
Compositions and methods for regulating immunometabolism and preventing and/or treating interferon-driven inflammation, including anti-inflammatory agents which upregulate fumarate hydratase enzymatic activity and/or expression of fumarate hydratase protein, and methods for preventing and/or treating inflammation in a patient in need thereof, wherein the methods comprise: administering an effective amount of a fumarate hydratase modulating agent to the patient.
Claims18
A method for prevention and/or treatment of inflammation in a patient in need thereof, the method comprising
- administering an effective amount of a fumarate hydratase modulating agent to said patient.
An anti-inflammatory agent for use in upregulating fumarate hydratase activity and/or expression to reduce or prevent interferon production, wherein the anti-inflammatory agent is selected from one or more of the following:
- fumarate hydratase;
- a small molecule activator of fumarate hydratase;
- a pharmaceutical composition comprising said small molecule activator of fumarate hydratase;
- a viral vector comprising a fumarate hydratase gene or mRNA thereof;
- or
- a non-viral vector, such as a lipid nanoparticle, comprising a fumarate hydratase gene or mRNA thereof.
Dependencies are inferred from the claim text.